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Coffee linked to slower biological ageing among those with severe mental illness

Is it possible that this phenomenon is specific to people with those mental illnesses? A wider general population study resulted in the inverse effect:

https://www.mdpi.com/2072-6643/15/6/1354

I only did a postgraduate degree, so I don't have the practice reading scientific studies to determine which is true. Maybe someone with more knowledge can chime in?

7 hours agodevilsdata

Separately from this study, here's an interesting opinion piece by John Ioannidis titled "The Challenge of Reforming Nutritional Epidemiologic Research", published in JAMA 2018:

https://statmodeling.stat.columbia.edu/wp-content/uploads/20...

  > Assuming the meta-analyzed evidence from cohort
  > studies represents life span–long causal associations, for
  > a baseline life expectancy of 80 years, eating 12 hazelnuts
  > daily (1 oz) would prolong life by 12 years (ie, 1 year per
  > hazelnut), drinking 3 cups of coffee daily would achieve
  > a similar gain of 12 extra years, and eating a single man-
  > darin orange daily (80 g) would add 5 years of life. Con-
  > versely, consuming 1 egg daily would reduce life expec-
  > tancy by 6 years, and eating 2 slices of bacon (30 g) daily
  > would shorten life by a decade, an effect worse than
  > smoking. Could these results possibly be true?
via Andrew Gelman's blog: https://statmodeling.stat.columbia.edu/2019/01/26/article-po...
6 hours agoshoo

these things are 100% true. I eat one hazelnut per hour and have lived already 230 years.

2 hours agoquaverquaver

also this explains squirrels

2 hours agoquaverquaver

Good thing I drink hazelnut coffee while eating eggs and bacon! It cancels out right?

2 hours agokfarr

Studies of larger populations yield more typical results. Consequently, studies of smaller populations yield more extreme results.

That's not to say that these results might not be significant -- what you propose may be the case -- but I'd want to see an actual mechanism of action before buying something like this.

6 hours ago11Spades

It's well-known that schizophrenics self-medicate with coffee and nicotine: https://en.wikipedia.org/wiki/Schizophrenia_and_tobacco_smok...

The inverse possibility--that nicotine, and perhaps caffeine as well, heighten the risk of psychosis in those genetially predisposed--has also been considered.

4 hours agoanonnon

Idk about the op study, but I could imagine confounders with instant coffee consumption.

7 hours agofoota

True, and it could also be what the person has with the coffee. I have a feeling people that drink instant coffee are more likely to add milk, creamer, or sugar.

That said, instant coffee is just freeze-dried coffee. There's a possibility its effect is no different.

7 hours agodevilsdata

I think it’s typically a different species (Coffea canephora). So theoretically drinking bean tea of a different plant could have different health impacts.

40 minutes agoVladVladikoff

No, it affects everybody. Says so in the article. The distinction appears to be that severe mental illness is associated with shortened lifespan so coffee has a more profound anti-aging affect on that population.

7 hours agotootie

Interesting. I wonder if that extends to any stimulant, or if it's something particular with caffeine and coffee.

With that said, the fact that the other study seemed to find the opposite conclusion concerns me.

6 hours agodevilsdata

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6 hours agohuijzer

Research doesn't show that dietary acids affect body pH that much.

There's massive buffer systems in the body.

6 hours agothe_real_cher

Yep, homeostasis

5 hours agocamel_gopher

Should people be unequally denied caffeinenated coffee on the basis of medical status as determined by a physician they must pay?

What about decaf only; 0.3% coffee?

Is decaf linked to slower biological aging, too?

5 hours agostopbulying

I wonder if what seems like much higher margins in coffee allow for more articles like this. While I want what they are saying to be true, I wish I did not have to pay $15.00 for a 26 ounce can of coffee.

7 hours agozafka

$10/lb sounds very reasonable for a grown, hand picked, fermented, washed, dried, shipped, roasted, packaged, and delivered seed.

6 hours agorottencupcakes

This is not expensive. In my part of the world I'm paying $15-20 for 250 g (9 oz).

6 hours agoorphea

Arguably one of you just has better taste in coffee, especially at ~$10/lb

12 minutes agoxethos

Is it possible that the coffee drinkers have more social interaction with the barista and others? It's unclear from the paper if they eliminated the confounding factors around coffee drinking.

4 hours agolow_tech_punk

Coffee can also be a very social thing right? In Denmark for example (Australia slightly less so) there are lots of social “coffee breaks” at work.

10 minutes agodaniel_iversen

Do people have social interactions with their barista?

3 hours agoagnishom

Yes

2 hours agoZambyte

As someone formally diagnosed with one of these mental illnesses, I can confidently say that coffee triggers a beneficial reaction to my illness as well as to other health-adjoint mechanisms in my body. To me, drinking coffee is like breathing air or eating food, and to go without it means symptom flare-ups.

7 hours agodjaouen

Sounds more like dependence/addiction to me

6 hours agotemp0826

Is it the coffee or caffeine in coffee? Do you feel the same benefits if you have decaffeinated coffee? Can you replace it with just caffeine pills to get same effect?

7 hours agobusymom0

I have not tried caffeine pills myself, but I have found caffeine in general to be slightly beneficial, but with coffee having the most pronounced effect on my symptoms.

7 hours agodjaouen

Likely an effect of MAO inhibitors in coffee. Caffeine itself is also a MAO inhibitor (in addition to its primary effect of adenosine receptor antagonism), but there are dozens of others in the brew.

6 hours agocluckindan

Liking coffee linked to ...

7 hours agobrikym

Do you like sweets? I noticed as I became an adult sometime in my mid-20s, I stopped liking sweet flavors as much and developed a new appreciation for bitter flavors. Like coffee and some vegetables.

7 hours agolowdest

My tastes changed a lot over the years. I quit liking sweets in my early 20s, I rarely even have sugar in the house.

Sometime in my late 30s I started appreciating more nuanced flavors, including black coffee, but mostly vegetables like green beans, tomatoes, asparagus, peas, carrots. Once that happened, I started realizing how much food is blasted with so much salt that obliterates said flavors.

I assume it's mostly normal, as a kid I found my parents tastes bland...ew who could eat vegetables by themselves with no seasoning? Well, me now apparently...

6 hours agosilisili

Same.

There was a time when my diet was consistently full of very sweet things -- in particular, with beverages: More soda? Another mocha latte swimming in sugar? Another quart of orange juice? Yes, please.

But also food: How can a person walk past a selection of fresh donuts without having one?

Eventually, for reasons that initially were budgetary more than anything else, I discovered some coffee that I really liked the natural flavor of at a local place. I started getting that -- plain, black -- instead of a latte, mostly because $2.10 is a lot less than $3.75.

That coffee was Ethiopian Yirgacheffe. This particular one had its own distinct, subtle sweetness that hit the spot for me and was part of a basically-daily feel-good routine for years until their roaster stopped selling it.

But by then, I was a black coffee convert. And I didn't even notice at the time, but I'd also stopped buying soda in bulk -- it became a rare entity in my life instead of a daily fixation.

I also stopped buying things like cookies and donuts. I began to skip the pie at gatherings.

That all happened in my 30s.

Nowadays, motivated only by what I feel like eating or drinking instead of some desire to make healthy choices or something, my intake is good-tasting spring water (the tap water here sometimes tastes of mud), decent black coffee, inexpensive tea, and [of course] beer.

My food has taken a turn for the bland, too.

I buy carrots and celery at the store to munch on, instead of a bag of cookies. Things like rice and beans and fish have an abundance of flavor that I wasn't able to appreciate before. For gatherings, I make a big relish tray full of fresh vegetables -- and I munch on them more than anyone else does.

I seldom buy breakfast cereal now, but I used to eat a lot of it -- and I'd load it up with more sugar. Last year I did buy some store-brand raisin bran but I found that it was too much of a sugar bomb to really enjoy as a meal. I couldn't make myself finish it; most of it wound up in the compost. (I did find some very plain bran flakes that I liked a lot better -- 12-year-old me would not have been impressed.)

This is all a bit weird to describe because the only deliberate decision involved was to try to save a bit of money on coffee-house coffee in my 30s.

But did that decision actually have anything to do with it? Or is this instead a tale as old as time itself, wherein: Tastes simply change?

(But yeah, I do enjoy an occasional sugar bomb. But only literally-occasionally. For instance: A single 12-ounce bottle of Coke is very nice sometimes. I probably drink as many as 2 or 3 of those in a whole year.)

5 hours agossl-3

Is this a quote? Or your own take?

7 hours agojagged-chisel

My own take. The point is that the link may be the other way around. The population of people who tend to drink coffee might age slower. Perhaps due to some third variable like wealth or race. Correlation is not causation.

5 hours agobrikym

That title smells of p-hacking

6 hours agotompccs

No, that was stale robusta

2 hours agopostsantum

Due to caffiene or something else?

7 hours agonrhrjrjrjtntbt

I think not the caffeine. The beneficial/healthy parts of coffee tend to be the coffee itself.

7 hours agoaetherspawn

3-4 cups of coffee is the exact amount you need to get through a workday, and only lower class types drink instant coffee.

All of these studies are hot garbage, hopelessly confounded, the biggest scam in science is "controlling for".

Do an RCT and watch the coffee magic evaporate.

4 hours agokuipferings

Without any documentation of actual caffeine consumption this study is completely worthless.

7 hours agoempressplay

how could it be worthless when it inspired such a valuable comment

7 hours agomicromacrofoot

I sure liked the first half of this title.

6 hours agojmonty900

But the second half of this title makes it an article worth forwarding to co-workers ;-)

2 hours agojasoneckert

> coffee consumption within the NHS recommended limit

5 hours agoNegativeLatency

Just enjoy some news and doom scrolling with your morning cuppa ;)

6 hours agochickensong

yup it's true, and as some point out, consumption in the early morning, when we all get a proinflammatory, normal response, is perfect timing for the antioxidant flood of coffee to counteract it all.

The rest of the day is another story, every day! Hopefully one of the better stories.

5 hours agoDaveZale

I've been starting days with a bowl 2/3rds full of frozen blueberries (microwaved 2mins to soften) plus greek yogurt and a dash of maple syrup.

It's a lot of blueberries. But I can afford $60/month in frozen blueberries. Plus they're tasty. Also antioxidants or whatever.

4 hours ago0_____0

That was my routine for a few years to ward off huntington’s disease. I don’t think the science panned out for blueberries and huntington’s, but in the mean time I got old enough to realize I didn’t have the genes for it (yes I was too cowardly to be tested)

an hour agoonionisafruit

If I had severe mental illness I'd be immortal by now.

7 hours agoekjhgkejhgk

My stomach hates coffee at the moment :(. Too acidic. Not sure I’m ever going to be able to have it regularly.

6 hours agomattgreenrocks

I cut coffee for a year or so 10 years ago due to stomach issues, then slowly added fancy espresso drinks back, figuring that if I was only having coffee once a week, it might as well be fancy. I don’t seem to have stomach issues now with 1-2 lattes/cappuccinos a day.

Maybe it’s unrelated, all in my head, better beans, or the 3-4 oz of whole milk, but maybe give espresso drinks a try if you haven’t?

3 hours agosunshinesnacks

Do you add whole milk to coffee? The casein and fat should help to reduce acidity and make it easier on the stomach.

If you can't do that, I've heard of people adding a sprinkle of baking soda as a buffer to black coffee. I'm not sure how much you'd need, probably just a tiny amount that you'd barely be able to taste.

6 hours agoesperent

Haven’t tried the latter, will give it a shot. Thank you!

4 hours agomattgreenrocks

I have ADHD, and I drink 2-3 cups' worth of coffee every day.

I'm basically a vampire now.

7 hours agodentemple

I've been self-medicating ADHD with multiple cups of coffee a day since I was 17. I'm in my early 30s now, and after getting on Vyvanse, have reduced then given up coffee. I realised that coffee was the reason for my anxiety which builds up towards the end of the day.

I reduced my coffee down to 1 espresso per day two months ago, and quit entirely two weeks ago. I'm still on stimulants, but Vyvanse treats ADHD much better and has fewer side-effects.

6 hours agodevilsdata

As a mentally ill vampire, I try to only feed on coffee drinkers.

6 hours agolayer8

Yesterday I drank a whole pot myself then had another cup or two. Keeps me in the game.

Where does that put me? Caffeine poisoning or immortality with no in between?

7 hours agodoubled112

> Too much coffee reduced this positive effect

6 hours agolostlogin

Well, I guess I have to die of something someday.

5 hours agodoubled112

> 2-3 cups' worth

> basically a vampire now.

Do you mean 2-3 liters?

5 hours agoekjhgkejhgk

How do you know you're not?

6 hours agobookofjoe
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4 hours ago

There can only be one. Or two. Maybe three. Four shoots espresso a day.

7 hours agoindubioprorubik

Lots of coffee related articles reaching the front page recently.

7 hours agoares623
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7 hours ago

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6 hours agotug2024

> within the NHS recommended limit

Over the NHS recommended limit is better than zero caffeine for everyone. If their limit is correct is in question

Whether "those with severe mental illness" get more benefit seems unlikely biologically. But like everyone coffee is good for you.

The only point of research like this, since we know coffee is good, is finding the mechanisms. But it's highly open to p-hacking/experimental error, which is how universities work now. You should default to this is citation farming.

6 hours agoNedF

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5 hours agonelox

Please stop. Article summaries have always been off topic on HN.

26 minutes agotomhow

These AI posts are annoying

4 hours agogreekrich92

The posts or the AI replies to them?

2 hours agocheschire

Even the ones born not on Mondays between 0700 and 1100?