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Cells use 'bioelectricity' to coordinate and make group decisions

For those interested in more details and quite mind blowing examples, here is a fascinating interview with Michael Levin (one of the researchers mentioned in the article).

https://youtu.be/c8iFtaltX-s?t=4751

Start at 1:19:11, the stuff before is him talking about biology, but from an intelligence perspective. After this time stamp is his retrospective on his bioelectricity research over the years, showing also examples of how they got a frog embryo to produce eyes, and many more things.

2 hours agojupiterelastica

Thanks for sharing this timestamp - Levin's retrospective on bioelectricity research is compelling. What fascinates me most is how his work challenges the gene-centric view of development. The experiments showing bioelectric patterns can override genetic instructions (like inducing eye formation in non-eye tissue) reveal a whole layer of morphogenetic information we're just beginning to understand.

2 hours agojoel_liu

Even since reading about Michael Levin's work, I've been sold that there is a lot going on in terms of bioelectricity outside of neurons. But I haven't seen that much progress. This is one interesting, albeit simple example.

>In this way, bioelectrical flow across cell membranes lets tissues test which cells are the least healthy and mark them for extrusion. “They’re always pushing against each other and bullying each other. And what they’re doing is probing each other for which one’s the weakest link,” Rosenblatt said. “It’s a community effect.”

This fits with my model of how high levels of cooperation succeed in biology. Even in a community as homogeneous as cells you have the risk of defectors (cancer), or just poor members. As such you need a process to continually test your community members.

11 hours agomarojejian

Electricity is the core of a single cell functionality as well, most biomolecules are on the exact boundary between a conductor and an insulator (and likely switch the state based on other molecules binding, pH, etc). A group of cells electricity is a higher level abstraction of that.

https://medium.com/the-physics-arxiv-blog/the-origin-of-life...

3 hours agomjanx123

makes me wonder what effect a low current flowing through the body would have on this process. would it hinder/disrupt this coordination?

3 hours agopyaamb

The article describes the mechanism in some detail near the end. As I understand it, it's not really "coordination" in the sense that they exchange messages through the electricity.

It's more that every cell has to maintain a voltage difference between the inside and outside ("membrane potential"). A healthy cell does that constantly using "ion pumps" that use chemical energy (ATP) to increase the potential.

If that potential falls below a certain threshold, certain molecular mechanisms (voltage-sensitive ion channels) inside the cell are triggered that lead to ejection.

Interestingly, are also other mechanisms (pressure-sensitive ion channels) that will "intentionally" make it harder for a cell to maintain its potential if it's already weakened or if the surrounding region is very crowded.

As such, I think the effect of current would depend on the way how it would change the voltage differences of the individual cells.

37 minutes agoxg15

Could this lead into how there are people who thing non ionising radiation sources affect them?

5 hours agojeffybefffy519

Why not simply say electricity?

5 hours agoFranklinJabar

Because that is useless? The physical phenomenon is so very, very different in biological systems compared to how people are used to that they are entirely different things!

For example, charge carriers are electrons in metal wires vs. ions in biological systems. That has huge implications, because moving around ions is a lot harder, and slower.

In a metal wire the electrical field is established from beginning to the end, and that means that the electrons at the end start moving at pretty much the same time as the ones at the other end, no matter how long the wire. That means in a metal wire signals move at a significant fraction of the speed of light in a vacuum, because it is the speed of the electrical field and not that of the charge carriers that matters.

In a biological system electrical fields are tiny! The way the signal propagates in an axon is much more cumbersome, expensive, and slow. Speed of signal propagation is ca. 1/2 to at most 100 m/s (for thick myelinated axons). The signal is propagated by jumping in very tiny steps along the axon's inner surface. (https://youtu.be/tOTYO5WrXFU)

This also makes The Matrix movies' main premise about humans as batteries a little strange: Sure, there's lots of electrical activity, but it is in trillions of very tiny places across nanometer distances. And it is created by moving ions around (at great energy cost).

So anyway, what actually physically happens in an electrical grid of metal wires, or in a biological system are vastly different things.

2 minutes agonosianu

The article notes that bioelectricity is just referring to electricity not occuring in the heart or brain which has a different specialized name. Simply saying electricity is captures more than the cell types reported on.

5 hours agoskyberrys

So this is sort of.. environmentally available electrical potential in the cell? Or is it more constrained than the venues from the heart and the cell to other specific venues?

4 hours agoFranklinJabar

You're rght. Light? thats just EMF. Infra Red? Emf. Xrays? It's all EMF man.

At least thats ITU regulated frequency bands. I wonder if the ITU regulates biogenic DC signalling frequencies?

5 hours agoggm

It'll blow their minds when they start researching chi kung and realise it's possible to draw in more energy by breathing and move it round the body. It's also possible to feel some kind of field around the body.

Auras and chakras don't sound so silly now do they.

3 hours agonprateem

> possible to draw in more energy by breathing and move it round the body

We already know what haemoglobin is thanks

an hour agoben_w

"It'll blow those Chemists' minds when they start researching Alchemy and they realize the incredible power of mercury and lead to rejuvenate the body and lead to an elixir of youth!"

"It'll blow those Astronomers' minds when they start researching Astrology and the powerful effect of being born under auspicious constellations!"

__________

If the ancient guru knowledge is so great, what testable predictions does it offer, where "auras" are a causal mechanism?

In other words, not: "Thou must intake the golden aura of oats and fiber by eating some, to counter the dark brown blockage of your Pu-point." The folk remedy might well solve your constipation, but it wouldn't be evidence for the mythology around it.

3 hours agoTerr_

Proper hatha yoga (not the modern hijacked nonsense) is literally a predictive method to experience deeper aspects of oneself, one part of which is a greater sensitivity to energy movements and corresponding fields.

There is already western research on kundalini, the most potent example of bioelectrical energy, and changes in energy potential experienced by meditators. Not to mention countless empirical self-reports (upon which a good scientist would keep an open mind).

But don't let facts get in the way of your prejudices.

an hour agonprateem

It feels really great to wield the scientific method and feel supercilious to all other people and ideas that do not arise from such infallible reasoning, and sure the progress of humanity hockey sticked since empiricism took hold. But let's not forget that empiricism is limited by what we can/want/think to measure.

Like it's pretty well accepted that breathing exercises have physiological and mental health benefits but it took decades of consumerist appropriation of yoga and other techniques before academia properly found the motivation to earnestly investigate that yes breathing exercises are indeed good for you.

As someone who is a deep practitioner of martial arts and athletics, if the metaphors of qi gong and yoga were purely powerful visualisation aids that already provides more than enough tangible benefit. I don't need scientists to tell me that qi is good for my body - I can feel it.

So let's keep an open mind, our ancestors were anything but idiots.

2 hours agodjtango

> So let's keep an open mind, our ancestors were anything but idiots.

Just not so open our brains fall out.

Our ancestors were just like us, but fewer in number and inventing things from scratch. Miasma, spontaneous generation, Newtonian gravity, these were not people being idiots, and even though they have been shown to be wrong they are still close enough to still be useful today. Phlogiston also wasn't idiotic, but lacks utility vs being correct about oxygen.

One of the shared ways we failed then and now is that what sounds true isn't the same as what is true; the modern easy example of this is how easily many of us get fooled by LLMs, and I suspect that's how a lot of ancient religions grew, with additions and copy-errors evolving them to be maximally plausible-sounding to a human mind.

35 minutes agoben_w

Lol no, this crank shit sounds dumb as fuck haha. Kamehameha!

an hour agorenewiltord

Michael Levine really opened my mind to phase space in biology.

4 hours agoinshard

Yes, but how do they handle Byzantine fault tolerance?

5 hours agobitwize

T-cells. :P