I keep track of GLP1s and write a lot about them (looking for negative side effects, research results, etc) and it is amazing how potent retatrutide is. It’s not simply a matter of “more agonists, more better” but it looks like Eli Lilly has really cracked it.
There is a large enthusiast community of the body building variety (who are usually first) who are already performing a bit of an unscheduled human trial and I have to say the results are amazing. We have both injectable retatrutide and pill form retatrutide to look forward to (pill form is unannounced but I have a hunch!).
Retatrutide is incredible in a mind altering way. I know 4 people on it, including myself. And all just love the way it makes you feel. You just don’t want to eat as much and you want to eat healthier. As far as I can tell, that is it. While I’m nervous there could be long term side effects, I think the health benefits of being at a healthy weight mean that for probably 50% of the developed world they would benefit from it.
Looking forward to more formal studies though!
Now that the drug has shown you what a more appropriate portion is, do you think you can manage that on your own without the drug?
The issue is not lack of knowledge about appropriate amounts to eat, it's the physical sensations and mental state of being satiated at those amounts and the self control to limit yourself when you are not.
All research points to a "no" answer - weight is regained, and quickly. Which helps explain why obesity is so prevalent - it is something in the brain's chemistry.
Weight would only be regained if you start eating more, no? I would think that would be hard to do if you've already seen what appropriate portions are.
I tried semaglutide and while it was effective for losing weight, it made working out impossible (felt exhausted and very sick as soon as hr went up) and it made hangovers awful. Is retatrutide any different?
I got food poisoning on a glp2 and it was the worst I've ever felt in my life for like a week because it it slows the digestion.
it was an edge case I had not considered.
How is everyone purchasing Retatrutide at this moment? It's still in phase 3 trials, and I keep hearing of people being on it. Not really seeing safe options with proper lab testing.
Other pharmaceuticals at the phase 3 stage (such as Buntanetap for Parkinson's disease) are super difficult to get, even with the right to try exemption in the US.
Wellness/Health clinics sourcing from China or compounding pharmacies, which themselves source the ingredients from China.
Yeah, I hear everyone talk about it like it’s just super easy to get…
they buy it from research peptide vendors
Does it alter you mind more than just your appetite for healthy food like you said? Is there a buzz or general mood lift as well?
If there's any mental effect, it's most likely from eating less food (and most likely healthier food) and feeling better because of that.
It doesn't increase your appetite for healthy food. It will punish you for eating bad food. "Don't eat that steak, you're going to have crazy stomach pain tomorrow if you do!"
What’s wrong with eating steak? Biologically I mean, not ethically.
Absolutely nothing, if you only eat a few ounces. But a lot of places will server you a 12 oz ribeye steak which has 900 calories all by itself. Add on a side of french fries and a sugary beverage and you get a days worth of calories in a single sitting.
When you are on a GLP medication, commonly your digestion slows and will make you really prone to constipation and acid reflux. I've learned to eat just 3-6 ozs when I do steak, and generally opt for the veggies instead of the potatoes now. Feel much better in the morning.
That's not my experience with tirzepatide. When it worked for me (which was a brief period, admittedly), it kind of turned me off fatty foods, and I wouldn't want to have pizza, for example, but I'd crave a chicken breast and boiled potato, or salad.
When it didn't work, one of the failure modes was that I still craved fatty/fried food, but I got terrible stomach pain from it, which is the worst of both worlds. If I'm still going to be unable to resist food, I don't want to be punished for it any more than I already am by being overweight!
> When it didn't work, one of the failure modes was that I still craved fatty/fried food, but I got terrible stomach pain from it
I saw this was a feature, not a bug.
For me, it was definitely a bug, because my issue is I can't restrain myself. I don't lose weight, I just get pains. If I could restrain myself, why do I need the medication?
Unfortunately, my experience with tirzepatide doesn't make me hopeful: It either gave me terrible diarrhea and sulfur burps, or it did nothing at all, even on 15mg. Hopefully retatrutide is different, but I'm not holding my breath.
It did work for around two weeks, though, and it was great. I constantly felt mildly carsick, so I didn't really want to eat anything, but also didn't have much trouble eating my macros.
Sorry to hear that. As a counterpoint for the peanut gallery I've been on tirzepatide for 5 months and lost 15 kg in the first 3 months, never going past a 1.25mg dose. I've only creeped up to 3mg since and keep losing around 0.3 kg per week. No side effects except for super mild nausea every now and then. I plan to stay at a similar or lower dose for the next couple of years.
I had the good fortune of responding well and being at a great starting point: despite being 40% body fat I exercised a lot and had great labs to begin with. Anecdotally I've found starting metabolic health to make a huge difference in dose response.
Thanks, everyone else I know who's tried it has had great results, I guess I'm just unlucky :/
How did you get to 15mg and only had it working for 2 weeks? The starting dose is 2.5mg and it takes many months to titrate up to 15mg. Most people never get to 15mg.
I've read hundreds of anecdotal experiences from people on these drugs, and haven't encountered anyone taking 15mg without success.
> How did you get to 15mg and only had it working for 2 weeks?
Shrug, it's a mystery to me as well. It did take many months to get to that point.
Everyone is different but I lost over 40lbs just by taking 5mg over about 5 months
Author spent a ton of time writing this up "for fun"...but glad people are still doing this and old school blogs. The effort required seems substantial...
Not sure about the AI style transfer images... sure it's a valid way to get the illustrations you want but I don't have to like it...
I hope it is more effective that Tirzepatide of which I am a rare nonresponder and have only gained weight.
I keep track of GLP1s and write a lot about them (looking for negative side effects, research results, etc) and it is amazing how potent retatrutide is. It’s not simply a matter of “more agonists, more better” but it looks like Eli Lilly has really cracked it.
There is a large enthusiast community of the body building variety (who are usually first) who are already performing a bit of an unscheduled human trial and I have to say the results are amazing. We have both injectable retatrutide and pill form retatrutide to look forward to (pill form is unannounced but I have a hunch!).
Retatrutide is incredible in a mind altering way. I know 4 people on it, including myself. And all just love the way it makes you feel. You just don’t want to eat as much and you want to eat healthier. As far as I can tell, that is it. While I’m nervous there could be long term side effects, I think the health benefits of being at a healthy weight mean that for probably 50% of the developed world they would benefit from it.
Looking forward to more formal studies though!
Now that the drug has shown you what a more appropriate portion is, do you think you can manage that on your own without the drug?
The issue is not lack of knowledge about appropriate amounts to eat, it's the physical sensations and mental state of being satiated at those amounts and the self control to limit yourself when you are not.
All research points to a "no" answer - weight is regained, and quickly. Which helps explain why obesity is so prevalent - it is something in the brain's chemistry.
Weight would only be regained if you start eating more, no? I would think that would be hard to do if you've already seen what appropriate portions are.
I tried semaglutide and while it was effective for losing weight, it made working out impossible (felt exhausted and very sick as soon as hr went up) and it made hangovers awful. Is retatrutide any different?
I got food poisoning on a glp2 and it was the worst I've ever felt in my life for like a week because it it slows the digestion.
it was an edge case I had not considered.
How is everyone purchasing Retatrutide at this moment? It's still in phase 3 trials, and I keep hearing of people being on it. Not really seeing safe options with proper lab testing.
Other pharmaceuticals at the phase 3 stage (such as Buntanetap for Parkinson's disease) are super difficult to get, even with the right to try exemption in the US.
Wellness/Health clinics sourcing from China or compounding pharmacies, which themselves source the ingredients from China.
Yeah, I hear everyone talk about it like it’s just super easy to get…
they buy it from research peptide vendors
Does it alter you mind more than just your appetite for healthy food like you said? Is there a buzz or general mood lift as well?
If there's any mental effect, it's most likely from eating less food (and most likely healthier food) and feeling better because of that.
It doesn't increase your appetite for healthy food. It will punish you for eating bad food. "Don't eat that steak, you're going to have crazy stomach pain tomorrow if you do!"
What’s wrong with eating steak? Biologically I mean, not ethically.
Absolutely nothing, if you only eat a few ounces. But a lot of places will server you a 12 oz ribeye steak which has 900 calories all by itself. Add on a side of french fries and a sugary beverage and you get a days worth of calories in a single sitting.
When you are on a GLP medication, commonly your digestion slows and will make you really prone to constipation and acid reflux. I've learned to eat just 3-6 ozs when I do steak, and generally opt for the veggies instead of the potatoes now. Feel much better in the morning.
That's not my experience with tirzepatide. When it worked for me (which was a brief period, admittedly), it kind of turned me off fatty foods, and I wouldn't want to have pizza, for example, but I'd crave a chicken breast and boiled potato, or salad.
When it didn't work, one of the failure modes was that I still craved fatty/fried food, but I got terrible stomach pain from it, which is the worst of both worlds. If I'm still going to be unable to resist food, I don't want to be punished for it any more than I already am by being overweight!
> When it didn't work, one of the failure modes was that I still craved fatty/fried food, but I got terrible stomach pain from it
I saw this was a feature, not a bug.
For me, it was definitely a bug, because my issue is I can't restrain myself. I don't lose weight, I just get pains. If I could restrain myself, why do I need the medication?
Unfortunately, my experience with tirzepatide doesn't make me hopeful: It either gave me terrible diarrhea and sulfur burps, or it did nothing at all, even on 15mg. Hopefully retatrutide is different, but I'm not holding my breath.
It did work for around two weeks, though, and it was great. I constantly felt mildly carsick, so I didn't really want to eat anything, but also didn't have much trouble eating my macros.
Sorry to hear that. As a counterpoint for the peanut gallery I've been on tirzepatide for 5 months and lost 15 kg in the first 3 months, never going past a 1.25mg dose. I've only creeped up to 3mg since and keep losing around 0.3 kg per week. No side effects except for super mild nausea every now and then. I plan to stay at a similar or lower dose for the next couple of years.
I had the good fortune of responding well and being at a great starting point: despite being 40% body fat I exercised a lot and had great labs to begin with. Anecdotally I've found starting metabolic health to make a huge difference in dose response.
Thanks, everyone else I know who's tried it has had great results, I guess I'm just unlucky :/
How did you get to 15mg and only had it working for 2 weeks? The starting dose is 2.5mg and it takes many months to titrate up to 15mg. Most people never get to 15mg.
I've read hundreds of anecdotal experiences from people on these drugs, and haven't encountered anyone taking 15mg without success.
> How did you get to 15mg and only had it working for 2 weeks?
Shrug, it's a mystery to me as well. It did take many months to get to that point.
Everyone is different but I lost over 40lbs just by taking 5mg over about 5 months
Author spent a ton of time writing this up "for fun"...but glad people are still doing this and old school blogs. The effort required seems substantial...
Not sure about the AI style transfer images... sure it's a valid way to get the illustrations you want but I don't have to like it...
I hope it is more effective that Tirzepatide of which I am a rare nonresponder and have only gained weight.
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